Page last updated: 2024-08-05 15:02:46

EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor

An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of succinate dehydrogenase (quinone), EC 1.3.5.1.

ChEBI ID: 83072

Members (8)

MemberDefinitionClass
2-chloro-n-(4-chlorobiphenyl-2-yl)nicotinamideA pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals.boscalid
3-nitropropionic acidA C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.3-nitropropanoic acid
carboxinAn anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment.carboxin
flutolanilA member of the class of benzamides, obtained by formal condensation of the carboxy group of 2-(trifluoromethyl)benzoic acid with the amino group of 3-(ispropyloxy)aniline. A fungicide used to control a range of pathogens especially Rhizoctonia spp. on rice, turf and other crops.flutolanil
fluxapyroxadAn aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those belonging to the Ascomycetes, Basidiomycetes and Zygomycetes families.fluxapyroxad
oxycarboxinAn anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-4,4-dioxo-1,4-oxathiine-3-carboxylic acid. A fungicide for the control of rust diseases on ornamentals, cereals and nursery trees as well as fairy rings on turf.oxycarboxin
thifluzamideAn aromatic amide obtained by formal condensation of the carboxy group of 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid with the amino group of 2,6-dibromo-4-(trifluoromethoxy)aniline. Used to control Rhizoctonia spp. diseases on rice, potatoes, maize, grass and other crops.thifluzamide
tolfenpyradAn aromatic amide obtained by formal condensation of the carboxy group of 4-chloro-3-ethyl-1-methylpyrazole-5-carboxylic acid with the amino group of 1-[4-(4-methylphenoxy)phenyl]methylamine.tolfenpyrad

Research

Studies (1,144)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199055 (4.81)18.7374
1990's162 (14.16)18.2507
2000's435 (38.02)29.6817
2010's368 (32.17)24.3611
2020's124 (10.84)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1 (0.08%)5.53%
Reviews41 (3.39%)6.00%
Case Studies8 (0.66%)4.05%
Observational0 (0.00%)0.25%
Other1,161 (95.87%)84.16%

Protein Targets (77)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency0.842822
acetylcholinesteraseHomo sapiens (human)Potency23.584145
activating transcription factor 6Homo sapiens (human)Potency27.471412
AR proteinHomo sapiens (human)Potency41.6265926
aryl hydrocarbon receptorHomo sapiens (human)Potency36.264239
Ataxin-2Homo sapiens (human)Potency49.197913
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency53.669124
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.631022
Cellular tumor antigen p53Homo sapiens (human)Potency40.860325
Chain A, HADH2 proteinHomo sapiens (human)Potency3.981111
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency7.943311
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency39.810711
Chain B, HADH2 proteinHomo sapiens (human)Potency3.981111
chromobox protein homolog 1Homo sapiens (human)Potency78.117112
cytochrome P450 2C9, partialHomo sapiens (human)Potency3.799612
cytochrome P450 2D6Homo sapiens (human)Potency41.484913
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency20.065613
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency31.699316
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
estrogen nuclear receptor alphaHomo sapiens (human)Potency36.7910826
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency55.345823
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency39.0071930
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency33.997212
farnesoid X nuclear receptorHomo sapiens (human)Potency49.893034
GVesicular stomatitis virusPotency3.799612
gemininHomo sapiens (human)Potency6.937423
GLI family zinc finger 3Homo sapiens (human)Potency29.383829
glp-1 receptor, partialHomo sapiens (human)Potency27.334222
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency30.802245
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency39.014316
Glycoprotein hormones alpha chainHomo sapiens (human)Potency22.387211
heat shock protein beta-1Homo sapiens (human)Potency48.115224
hemoglobin subunit betaHomo sapiens (human)Potency12.589311
histone deacetylase 9 isoform 3Homo sapiens (human)Potency26.528524
Histone H2A.xCricetulus griseus (Chinese hamster)Potency9.267011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency3.799612
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency53.340613
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency25.118922
IDH1Homo sapiens (human)Potency9.200011
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency3.799714
Interferon betaHomo sapiens (human)Potency3.799612
lamin isoform A-delta10Homo sapiens (human)Potency6.309611
LuciferasePhotinus pyralis (common eastern firefly)Potency52.058024
mitogen-activated protein kinase 1Homo sapiens (human)Potency3.162311
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency0.063111
Nrf2Homo sapiens (human)Potency28.183811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency34.1595411
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency29.092911
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency1.493013
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency31.9705314
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency125.892011
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency26.915736
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency30.2867512
pregnane X nuclear receptorHomo sapiens (human)Potency27.962227
pregnane X receptorRattus norvegicus (Norway rat)Potency41.803613
progesterone receptorHomo sapiens (human)Potency40.502326
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency56.234111
RAR-related orphan receptor gammaMus musculus (house mouse)Potency24.8020210
regulator of G-protein signaling 4Homo sapiens (human)Potency100.000011
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency36.4433313
retinoid X nuclear receptor alphaHomo sapiens (human)Potency24.4675410
SMAD family member 2Homo sapiens (human)Potency54.941011
SMAD family member 3Homo sapiens (human)Potency54.941011
TAR DNA-binding protein 43Homo sapiens (human)Potency0.562311
TDP1 proteinHomo sapiens (human)Potency36.625728
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.707911
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency51.145126
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency39.810711
thyroid stimulating hormone receptorHomo sapiens (human)Potency31.764324
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency30.147511
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency59.164123
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency39.0165510
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency39.014316

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Delta-aminolevulinic acid dehydrataseEscherichia coli K-12Ki44,900.000011
Isocitrate lyaseCandida albicansIC5032.61641111
Isocitrate lyaseMycobacterium tuberculosis H37RvIC50116.000011
Isocitrate lyase 1Mycobacterium tuberculosis CDC1551IC5014.700011