An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of succinate dehydrogenase (quinone), EC 1.3.5.1.
Member | Definition | Class |
2-chloro-n-(4-chlorobiphenyl-2-yl)nicotinamide | A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals. | boscalid |
3-nitropropionic acid | A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group. | 3-nitropropanoic acid |
carboxin | An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment. | carboxin |
flutolanil | A member of the class of benzamides, obtained by formal condensation of the carboxy group of 2-(trifluoromethyl)benzoic acid with the amino group of 3-(ispropyloxy)aniline. A fungicide used to control a range of pathogens especially Rhizoctonia spp. on rice, turf and other crops. | flutolanil |
fluxapyroxad | An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those belonging to the Ascomycetes, Basidiomycetes and Zygomycetes families. | fluxapyroxad |
oxycarboxin | An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-4,4-dioxo-1,4-oxathiine-3-carboxylic acid. A fungicide for the control of rust diseases on ornamentals, cereals and nursery trees as well as fairy rings on turf. | oxycarboxin |
thifluzamide | An aromatic amide obtained by formal condensation of the carboxy group of 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid with the amino group of 2,6-dibromo-4-(trifluoromethoxy)aniline. Used to control Rhizoctonia spp. diseases on rice, potatoes, maize, grass and other crops. | thifluzamide |
tolfenpyrad | An aromatic amide obtained by formal condensation of the carboxy group of 4-chloro-3-ethyl-1-methylpyrazole-5-carboxylic acid with the amino group of 1-[4-(4-methylphenoxy)phenyl]methylamine. | tolfenpyrad |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
67.9K protein | Vaccinia virus | Potency | 0.8428 | 2 | 2 |
acetylcholinesterase | Homo sapiens (human) | Potency | 23.5841 | 4 | 5 |
activating transcription factor 6 | Homo sapiens (human) | Potency | 27.4714 | 1 | 2 |
AR protein | Homo sapiens (human) | Potency | 41.6265 | 9 | 26 |
aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 36.2642 | 3 | 9 |
Ataxin-2 | Homo sapiens (human) | Potency | 49.1979 | 1 | 3 |
ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 53.6691 | 2 | 4 |
Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 2 | 2 |
Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 40.8603 | 2 | 5 |
Chain A, HADH2 protein | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
Chain B, HADH2 protein | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 78.1171 | 1 | 2 |
cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 3.7996 | 1 | 2 |
cytochrome P450 2D6 | Homo sapiens (human) | Potency | 41.4849 | 1 | 3 |
cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 20.0656 | 1 | 3 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 31.6993 | 1 | 6 |
DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 36.7910 | 8 | 26 |
estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 55.3458 | 2 | 3 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 39.0071 | 9 | 30 |
euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 49.8930 | 3 | 4 |
G | Vesicular stomatitis virus | Potency | 3.7996 | 1 | 2 |
geminin | Homo sapiens (human) | Potency | 6.9374 | 2 | 3 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 29.3838 | 2 | 9 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 27.3342 | 2 | 2 |
glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 30.8022 | 4 | 5 |
Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 39.0143 | 1 | 6 |
Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
heat shock protein beta-1 | Homo sapiens (human) | Potency | 48.1152 | 2 | 4 |
hemoglobin subunit beta | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 26.5285 | 2 | 4 |
Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 9.2670 | 1 | 1 |
HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 3.7996 | 1 | 2 |
hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 53.3406 | 1 | 3 |
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
IDH1 | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 3.7997 | 1 | 4 |
Interferon beta | Homo sapiens (human) | Potency | 3.7996 | 1 | 2 |
lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 52.0580 | 2 | 4 |
mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0631 | 1 | 1 |
Nrf2 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 34.1595 | 4 | 11 |
nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 1.4930 | 1 | 3 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.9705 | 3 | 14 |
parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.9157 | 3 | 6 |
peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 30.2867 | 5 | 12 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 27.9622 | 2 | 7 |
pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 41.8036 | 1 | 3 |
progesterone receptor | Homo sapiens (human) | Potency | 40.5023 | 2 | 6 |
Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 24.8020 | 2 | 10 |
regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 36.4433 | 3 | 13 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 24.4675 | 4 | 10 |
SMAD family member 2 | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
SMAD family member 3 | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
TDP1 protein | Homo sapiens (human) | Potency | 36.6257 | 2 | 8 |
thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.7079 | 1 | 1 |
thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 51.1451 | 2 | 6 |
thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.7643 | 2 | 4 |
thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 30.1475 | 1 | 1 |
v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 59.1641 | 2 | 3 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 39.0165 | 5 | 10 |
Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 39.0143 | 1 | 6 |